Chronic itch is the dominating symptom of atopic dermatitis (AD). Antihistamines have
been used to reduce the intensity of itch caused by AD, but these agents are effective
only in some patients [
[1]
]. Histidine decarboxylase (HDC) is the enzyme that catalyzes the synthesis of histamine.
Previous studies on mice treated with topical surfactants show that an increase in
epidermal HDC is associated with itch-related behavior [
[2]
] and chronic pruritus with unknown cause induces monkey epidermal HDC [
[3]
]. These findings suggest that increased HDC expression in the epidermis plays a role
in itch. In this study, we investigated the correlation between epidermal HDC and
visual analogue scale (VAS; score range: 0–10) in patients with AD and identified
the cells expressing HDC in the epidermis.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Published online: June 10, 2021
Accepted:
June 8,
2021
Received in revised form:
May 20,
2021
Received:
February 10,
2021
Identification
Copyright
© 2021 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
