Comedo, a clogged hair follicle, is one of the predisposing factors of acne. Comedo
formation has been known to result from obstruction of the follicular orifice by hyperkeratosis,
followed by sebum coagulation with corneocytes in the follicle [
[1]
]. However, since this process cannot sufficiently explain the formation of open comedo
and microcomedo, where the follicular orifice is open, the detailed mechanism of comedo
formation remains to be elucidated. In this study, we performed immunological and
histological analyses using the follicular plug of the human nose and excised human
skin, including clogged hair follicles, to investigate the mechanism of comedo formation.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Dermatological ScienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Acne vulgaris.in: Fitzpatrick’s Dermatology. McGraw-Hill Inc., US2019: 1391-1418
- The human keratins: biology and pathology.Histochem. Cell Biol. 2008; 129: 705-733
- Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and β-Catenin.Stem Cells. 2008; 26: 1241-1252
- PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in vitro and sebaceous gland size in vivo.Biochim. Biophys. Acta - Gen. Subj. 2013; 1830: 4642-4649
- Holocrine secretion occurs outside the tight junction barrier in multicellular glands: lessons from claudin-1–deficient mice.J. Invest. Dermatol. 2020; 140: 298-308
- Inactivation of autophagy leads to changes in sebaceous gland morphology and function.Exp. Dermatol. 2018; 27: 1142-1151
- Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages.Autophagy. 2020; 16: 932-945
- p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.J. Cell Biol. 2005; 171: 603-614
- Holocrine secretion of sebum is a unique DNase2-dependent mode of programmed cell death.J. Invest. Dermatol. 2017; 137: 587-594
- Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxides.Br. J. Dermatol. 1983; 109: 191-198https://doi.org/10.1111/j.1365-2133.1983.tb07080.x
Article info
Publication history
Published online: June 22, 2022
Accepted:
June 20,
2022
Received in revised form:
May 25,
2022
Received:
January 21,
2022
Identification
Copyright
© 2022 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.
