Advertisement

Staphylococcus aureus phenol-soluble modulins induce itch sensation

      Atopic dermatitis (AD) is one of the most common debilitating inflammatory skin diseases and often results in lifelong burdens for affected patients. Staphylococcus aureus (S. aureus) colonization has been found in the lesional skin of a majority of AD patients and can exacerbate the inflammatory responses [
      • Geoghegan J.A.
      • Irvine A.D.
      • Foster T.J.
      Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship.
      ]. However, how S. aureus colonization contributes to chronic itch, one of the hallmark features of AD, is unknown.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Dermatological Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Geoghegan J.A.
        • Irvine A.D.
        • Foster T.J.
        Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship.
        Trends Microbiol. 2018; 26: 484-497
        • Nakamura Y.
        • Oscherwitz J.
        • Cease K.B.
        • Chan S.M.
        • Munoz-Planillo R.
        • Hasegawa M.
        • Villaruz A.E.
        • Cheung G.Y.
        • McGavin M.J.
        • Travers J.B.
        • et al.
        Staphylococcus delta-toxin induces allergic skin disease by activating mast cells.
        Nature. 2013; 503: 397-401
        • Blake K.J.
        • Baral P.
        • Voisin T.
        • Lubkin A.
        • Pinho-Ribeiro F.A.
        • Adams K.L.
        • Roberson D.P.
        • Ma Y.C.
        • Otto M.
        • Woolf C.J.
        • et al.
        Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.
        Nat. Commun. 2018; 9: 37
        • Chiu I.M.
        • Heesters B.A.
        • Ghasemlou N.
        • Von Hehn C.A.
        • Zhao F.
        • Tran J.
        • Wainger B.
        • Strominger A.
        • Muralidharan S.
        • Horswill A.R.
        • et al.
        Bacteria activate sensory neurons that modulate pain and inflammation.
        Nature. 2013; 501: 52-57
        • Shimada S.G.
        • LaMotte R.H.
        Behavioral differentiation between itch and pain in mouse.
        Pain. 2008; 139: 681-687
        • Guo C.J.
        • Grabinski N.S.
        • Liu Q.
        Peripheral Mechanisms of Itch.
        J. Invest Dermatol. 2022; 142: 31-41
        • Steele H.R.
        • Xing Y.
        • Zhu Y.
        • Hilley H.B.
        • Lawson K.
        • Nho Y.
        • Niehoff T.
        • Han L.
        MrgprC11(+) sensory neurons mediate glabrous skin itch.
        Proc. Natl. Acad. Sci. USA. 2021; 118: 15
        • Basbaum A.I.
        • Bautista D.M.
        • Scherrer G.
        • Julius D.
        Cellular and molecular mechanisms of pain.
        Cell. 2009; 139: 267-284
        • LaMotte R.H.
        • Shimada S.G.
        • Sikand P.
        Mouse models of acute, chemical itch and pain in humans.
        Exp. Dermatol. 2011; 20: 778-782
        • Silverberg J.I.
        • Gelfand J.M.
        • Margolis D.J.
        • Boguniewicz M.
        • Fonacier L.
        • Grayson M.H.
        • Chiesa Fuxench Z.C.
        • Simpson E.L.
        • Ong P.Y.
        Pain is a common and burdensome symptom of atopic dermatitis in United States adults.
        J. Allergy Clin. Immunol. Pr. 2019; 7 (e2697): 2699-2706