Advertisement

Ultraviolet B irradiation leads to the development of experimental bullous pemphigoid targeting BPAG1e

Published:December 05, 2022DOI:https://doi.org/10.1016/j.jdermsci.2022.12.001
      Antibodies in the serum of patients with bullous pemphigoid (BP) target two hemidesmosomal proteins, BP180 and BP230/bullous pemphigoid antigen (BPAG)1e [
      • Bernard P.
      • Didierjean L.
      • Denis F.
      • Saurat J.H.
      • Bonnetblanc J.M.
      Heterogeneous bullous pemphigoid antibodies: Detection and characterization by immunoblotting when absent by indirect immunofluorescence.
      ]. In patients with BP who have only anti-BPAG1e antibodies, the autoantibodies primarily react with the C-terminal domain of BPAG1e (BPAG1e-C) [
      • Hamada T.
      • Nagata Y.
      • Tomita M.
      • Salmhofer W.
      • Hashimoto T.
      Bullous pemphigoid sera react specifically with various domains of BP230, most frequently with C-terminal domain, by immunoblot analyses using bacterial recombinant proteins covering the entire molecule.
      ,
      • Hayakawa T.
      • Teye K.
      • Hachiya T.
      • Uehara R.
      • Hashiguchi M.
      • Kawakami T.
      • et al.
      Clinical and immunological profiles of anti-BP230-type bullous pemphigoid: Restriction of epitopes to the C-terminal domain of BP230, shown by novel ELISAs of BP230-domain specific recombinant proteins.
      ]. Recently, we found that adoptive transfer of splenocytes from conditional knockout (K5-Cre;Bpag1-/-) mice immunized with murine BPAG1e-C leads to BP-like phenotypes in the recipient immunodeficient mice [
      • Makita E.
      • Matsuzaki Y.
      • Fukui T.
      • Matsui A.
      • Minakawa S.
      • Nakano H.
      • et al.
      Autoantibodies to BPAG1e trigger experimental bullous pemphigoid in mice.
      ].

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Dermatological Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bernard P.
        • Didierjean L.
        • Denis F.
        • Saurat J.H.
        • Bonnetblanc J.M.
        Heterogeneous bullous pemphigoid antibodies: Detection and characterization by immunoblotting when absent by indirect immunofluorescence.
        J. Invest. Dermatol. 1989; 92: 171-174
        • Hamada T.
        • Nagata Y.
        • Tomita M.
        • Salmhofer W.
        • Hashimoto T.
        Bullous pemphigoid sera react specifically with various domains of BP230, most frequently with C-terminal domain, by immunoblot analyses using bacterial recombinant proteins covering the entire molecule.
        Exp. Dermatol. 2001; 10: 256-263
        • Hayakawa T.
        • Teye K.
        • Hachiya T.
        • Uehara R.
        • Hashiguchi M.
        • Kawakami T.
        • et al.
        Clinical and immunological profiles of anti-BP230-type bullous pemphigoid: Restriction of epitopes to the C-terminal domain of BP230, shown by novel ELISAs of BP230-domain specific recombinant proteins.
        Eur. J. Dermatol. 2016; 26: 155-163
        • Makita E.
        • Matsuzaki Y.
        • Fukui T.
        • Matsui A.
        • Minakawa S.
        • Nakano H.
        • et al.
        Autoantibodies to BPAG1e trigger experimental bullous pemphigoid in mice.
        J. Invest. Dermatol. 2021; 141: 1167-1176. e3
        • Kowalski E.H.
        • Kneibner D.
        • Kridin K.
        • Amber K.T.
        Serum and blister fluid levels of cytokines and chemokines in pemphigus and bullous pemphigoid.
        Autoimmun. Rev. 2019; 18: 526-534
        • Narumi H.
        • Nakano H.
        • Matsuzaki Y.
        • Sawamura D.
        • Hanada K.
        Immunohistochemical analysis of in vivo UVB-induced secretion of IL-1α and IL-6 in keratinocytes.
        Mol. Med. Rep. 2011; 4: 611-614
        • Ceryn J.
        • Skibińska M.
        • Barasińska P.
        • Noweta M.
        • Narbutt J.
        • Lesiak A.
        UVB-induced bullous pemphigoid in a patient with psoriasis.
        Post. Dermatol. Alergol. 2022; 39: 228-230
        • Mihara M.
        • Ohsugi Y.
        Possible role of IL-6 in pathogenesis of immune complex-mediated glomerulonephritis in NZB/W FL mice: Induction of IGG class anti-DNA autoantibody production.
        Int. Arch. Allergy Appl. Immunol. 1990; 93: 89-92
        • Schmidt E.
        • Reimer S.
        • Kruse N.
        • Jainta S.
        • Bröcker E.B.
        • Marinkovich M.P.
        • Giudice G.J.
        • Zillikens D.
        Autoantibodies to BP180 associated with bullous pemphigoid release interleukin-6 and interleukin-8 from cultured human keratinocytes.
        J. Invest. Dermatol. 2000; 115: 842-848