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FLG mutations, Eczema Control, and Respiratory Symptom at One-Year-Old in Early-Onset Atopic Dermatitis Infants (PACI-ON Cohort Study)

      FLG mutations are an important genetic risk factor for atopic dermatitis (AD) onset. FLG mutations increased the risk of not later-onset but early-onset AD from the Japanese general birth cohort [
      • Koseki R.
      • Morii W.
      • Noguchi E.
      • Ishikawa M.
      • Yang L.
      • Yamamoto-Hanada K.
      • Narita M.
      • Saito H.
      • Ohya Y.
      Effect of filaggrin loss-of-function mutations on atopic dermatitis in young age: a longitudinal birth cohort study.
      ]. Furthermore, FLG mutations were associated with food allergy, allergic rhinitis, and asthma with eczema [
      • Kono M.
      • Akiyama M.
      • Inoue Y.
      • Nomura T.
      • Hata A.
      • Okamoto Y.
      • Takeichi T.
      • Muro Y.
      • McLean W.H.I.
      • Shimizu H.
      • Sugiura K.
      • Suzuki Y.
      • Shimojo N.
      Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children.
      ,
      • Osawa R.
      • Akiyama M.
      • Shimizu H.
      Filaggrin gene defects and the risk of developing allergic disorders.
      ]. Early-onset AD was also a risk factor for developing various allergic diseases, such as food allergy [
      • Yamamoto-Hanada K.
      • Suzuki Y.
      • Yang L.
      • Saito-Abe M.
      • Sato M.
      • Mezawa H.
      • Nishizato M.
      • Kato N.
      • Ito Y.
      • Hashimoto K.
      • Ohya Y.
      • Japan E.
      G. Children's Study, Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort.
      ,
      • Roduit C.
      • Frei R.
      • Depner M.
      • Karvonen A.M.
      • Renz H.
      • Braun-Fahrlander C.
      • Schmausser-Hechfellner E.
      • Pekkanen J.
      • Riedler J.
      • Dalphin J.C.
      • von Mutius E.
      • Lauener R.P.
      • the Psg
      • Hyvarinen A.
      • Kirjavainen P.
      • Remes S.
      • Roponen M.
      • Dalphin M.L.
      • Kaulek V.
      • Ege M.
      • Genuneit J.
      • Illi S.
      • Kabesch M.
      • Schaub B.
      • Pfefferle P.I.
      • Doekes G.
      , Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.
      ]. In this study, we focused the infants with early-onset AD to determine whether FLG mutations influenced subsequent AD control and respiratory symptoms. We comprehensively screened early-onset AD infants in Japan for 10 FLG mutations specific to the Japanese population and compared infants with and without FLG mutations for AD and allergic outcomes at 12 months old.

      Abbreviations:

      AD (Atopic dermatitis), EASI (Eczema Area and Severity Index), FLG (Filaggrin gene), PACI (Prevention of Allergy via Cutaneous Intervention), POEM (Patient-Oriented Eczema Measure), TARC (Thymus and activation-regulated chemokine)

      Keywords

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