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Letter to the Editor|Articles in Press

Sex-specific association of SELL gene polymorphisms with pattern hair loss in the Thai population: A candidate gene association study and in silico functional characterization

Published:February 14, 2023DOI:https://doi.org/10.1016/j.jdermsci.2023.02.003
      Pattern hair loss (PHL) is a common heritable trait affecting both males and females (MPHL and FPHL, respectively). Although follicular miniaturization is the hallmark of PHL, assumptions implicating inflammatory infiltration around perifollicular areas have received attention. Leukocyte migration requires L-selectin, which is encoded by SELL. Several genes, including AR and SRD5A2, were associated with PHL under a non-Asian genetic architecture in a previous genome-wide association study [
      • Heilmann-Heimbach S.
      • Herold C.
      • Hochfeld L.M.
      • Hillmer A.M.
      • Nyholt D.R.
      • Hecker J.
      • et al.
      Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.
      ]. However, no study has yet evaluated the possible genetic effects of SELL polymorphisms in PHL. Thus, we decided to investigate the possible relationship between the genetic variation of SELL and PHL in the Thai population.
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