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Abstract
The major biochemical components of the mammalian hair are the intermediate filaments
or keratins and the keratin associated proteins. Keratin associated proteins are classified
into two groups (high-cysteine and high glycine-tyrosine-rich polypeptides) according
to the content of these amino acids. Cysteine-rich group contains high sulphur (16–24%
cysteine) and ultra-high sulphur (> 30% cysteine) proteins. We report here the identification
of a human sequence presumably coding for a new ultra-high sulphur protein (hUHSp21)
and the isolation and characterization of four genomic clones containing six related
sequences. We also discuss the possibility that all the genes encoding keratin associated
proteins are evolutionary related. These human clones should provide useful molecular
tools for studies of hair differentiation and understanding of the molecular basis
of human trichothiodystrophy.
Keywords
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Article info
Publication history
Accepted:
March 15,
1996
Received in revised form:
March 11,
1996
Received:
December 26,
1995
Identification
Copyright
© 1997 Published by Elsevier Inc.
