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Research paper| Volume 14, ISSUE 1, P45-53, January 1997

Apoptotic pocket-like structures of the bulge of the terminal hair follicles of the human scalp

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      Abstract

      Terminal hair follicles of the human scalp of all ages showed apoptotic pocket-like structures in the outer root sheath of the bulge area at anagen, but not telogen phase. The occurence of these hole structures was roughly estimated in 15% of anagen terminal hair follicles of the human scalp. The size of these apoptotic pockets was variable, ranging from pin hole-like spaces to larger structures filled with homogeneous black materials. These unusual variations were often co-localized with apoptotic degenerations and exclusively present in the presumptive bulge of anagen terminal hair follicles where arrector pili muscles were seen in the vicinity. In fact, these vacuolated structures tended to be present on the side where the major part of the arrector pili muscles anchored.

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      References

        • Unna PG
        Beitrage zur Histologie und Entwicklungsges-chicht der menschlichen Oberhaut und Anhangsgeblilde.
        Arch Microskop Anat Entwicklungsmech. 1876; 12: 665-741
        • Narisawa Y
        • Hashimoto K
        • Kohda H
        Two- and three-dimensional observations of human terminal and vellus hair follicles.
        J Dermatol Sci. 1994; 7: S13-S19
        • Narisawa Y
        • Hashimoto K
        • Kohda H
        Scanning electron microscopic observations of extracted terminal hair follicles of the adult human scalp and eyebrow — Special references to the bulge areas.
        Arch Dermatol Res. 1995; 287: 599-607
        • Narisawa Y
        • Hashimoto K
        • Kohda H
        Epithelial skirt and bulge of human facial vellus hair follicles and associated Merkel cell-nerve comlex.
        Arch Dermatol Res. 1993; 285: 269-277
      1. Narisawa Y, Kohda H, Tanaka T: Three-dimensional demonstration of melanocyte distribution of human hair follicles — special reference to the bulge area. Submitted for publication.

        • Cohen JJ
        Apoptosis.
        Immunol Today. 1993; 14: 126-130
        • Cohen JJ
        • Duke RC
        • Fadok VA
        • Sellins KS
        Apoptosis and programmed cell death in immunonity.
        Annu Rev Immunol. 1992; 10: 267-293
        • Weedon D
        The lichenoid tissue reaction.
        J Cutan Pathol. 1985; 12: 279-281
        • Seiberg M
        • Marthinuss J
        • Stenn KS
        Changes in expression of apoptosis-associated genes in skin mark early catagen.
        J Invest Dermatol. 1995; 104: 78-82
        • Weedon D
        Apoptosis.
        Adv Dermatol. 1990; 5: 243-256
        • Haake AR
        • Polakowska RR
        Cell death by apoptosis in epidermal biology.
        J Invest Dermatol. 1993; 101: 107-112
        • Narisawa Y
        • Hashimoto K
        • Kohda H
        Merkel cells of the terminal hair follicle of the adult human scalp.
        J Invest Dermatol. 1994; 102: 506-510
        • Montagna W
        • Van Scott EJ
        The anatomy of the hair follicle.
        in: Montagna W Van Scott EJ The Biology of Hair Growth. Academic Press, New York1958: 39-64
        • Epstein WL
        • Maibach HI
        Cell proliferation and movement in human hair bulbs.
        in: Montagna W Dobson RL Hair Growth. Pergamon Press, New York1969: 83-97
        • Headington JT
        Transverse microscopic anatomy of the human scalp A basis for a morphometric approach to disorders of the hair follicle.
        Arch Dermatol. 1984; 120: 449-456
        • Sperling LC
        Hair anatomy for the clinician.
        J Am Acad Dermatol. 1991; 25: 1-17
        • Hurle JM
        Cell death in development systems.
        Methods Achiev Exp Pathol. 1988; 13: 55-86
        • Terada T
        • Nakanuma Y
        Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct developpment.
        Am J Pathol. 1995; 146: 67-74
        • Narisawa Y
        • Kohda H
        Two- and three-dimensional demonstrations of morphological alterations of early anagen hair follicle — special reference to the bulge.
        Arch Dermatol Res. 1996; 288: 98-102
        • Desmet VJ
        Congenital disease of intrahepatic bile ducts: variations on the theme ‘ductal plate malformation’.
        Hepatology. 1992; 16: 1069-1083