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Abstract
Traditional herbal medicines with anti-herpes simplex virus type 1 (HSV-1) activity
in vivo were examined for their prophylactic effects on recurrent HSV-1 infection
in mice. Mice were intradermally infected with HSV-1 in the pinna and recurrent HSV-1
disease was induced by ultraviolet irradiation. Herbal extracts arrested the progression
of recurrent HSV-1 disease, reduced the incidence of severe erythema and/or vesicles
in the pinna, and/or shortened the period of severe recurrent lesions compared with
water-administered mice (P < 0.01 or 0.05). Similarly, the prophylactic treatment of herbal extracts limited
the development of recurrent skin lesions induced by stripping with cellophane tape
physically. The prophylactic efficacy on recurrence was confirmed by the absence of
HSV DNA in the skin lesions. HSV-1 genome was revealed to exist in the trigeminal
ganglia but not in the pinna of latently infected mice before stimuli by a nested-polymerase
chain reaction assay. After stimuli, HSV-1 genome was detected in both pinna and trigeminal
ganglia of latently infected mice administered with water. However, prophylactic treatment
decreased the rate of detection of HSV-1 genome in the stimulated pinna. Thus, the
herbal extracts exhibited prophylactic efficacy against recurrent HSV-1 disease in
mice and modulated the recurrent HSV-1 infection.
Keywords
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Article info
Publication history
Accepted:
May 27,
1996
Received in revised form:
May 16,
1996
Received:
March 28,
1996
Identification
Copyright
© 1997 Published by Elsevier Inc.
