Research Article| Volume 17, ISSUE 2, P101-107, June 1998

A variety of skin responses to ultraviolet irradiation in patients with atopic dermatitis


      Skin responses to ultraviolet irradiation in patients with atopic dermatitis were studied to evaluate the role of sunlight in the exacerbation of atopic dermatitis. A total of 15 patients, seven males and eight females, with atopic dermatitis who complained of exacerbation of their dermatitis after sun exposure were examined by photo testing with UVB and UVA irradiation and photopatch tests. Nine out of 15 patients showed abnormal skin reactions. Lowered minimal erythema doses (MEDs) to a single exposure of UVB, papular or erythematous responses after single or repeated exposures to UVB or UVA and positive photopatch test reactions to sunscreen ingredients and fragrances were found. There are apparently multiple mechanisms of photoexacerbation in patients with atopic dermatitis.


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        • Hawk JLM
        Cutaneous photobiology.
        in: Champion RH Bruton JL Ebling FJG Rook/Wilkinson/Ebling Textbook of dermatology. Blackwell, Oxford1992: 865
        • Ohno S
        • Fujita M
        • Miyachi Y
        Two case of atopic dermatitis with photosensitivity.
        Acta Dermatol Kyoto. 1992; 87: 141-144
        • Keong CH
        • Kurumaji Y
        • Miyamoto C
        • Fukuro S
        • Kondo S
        • Nishioka K
        Photosensitivity in atopic dermatitis: demonstration of abnormal response to UVB.
        J Dermatol. 1992; 19: 342-347
        • Hanifin JM
        • Rajka G
        Diagnostic feature of atopic dermatitis.
        Acta Derm-Venereol Suppl (Stockh). 1980; 92: 44-47
        • Lim HW
        • Morison WL
        • Kamide R
        • Buchness MR
        • Harris R
        • Soter NA
        Chronic actinic dermatitis. An analysis of 51 patients evaluated in the United States and Japan.
        Arch Dermatol. 1994; 130: 1284-1289
        • Thune P
        • Jansen C
        • Wennersten G
        • Rystedt I
        • Brodthagen H
        • McFadden N
        The Scandinavian multicenter photopatch study 1980–1985: final report.
        Photodermatology. 1988; 5: 261-269
        • Wilkinson DS
        • Fregert S
        • Magnusson B
        • Bandmann HJ
        • Calnan CD
        • Cronin E
        • Hjorth N
        • Maibach HJ
        • Malten KE
        • Meneghini CL
        • Pirila V
        Terminology of contact dermatitis.
        Acta Derm-Venereol. 1970; 50: 287-292
        • Pigatto PD
        • Altomare G
        • Pilenghi MM
        • Roveroni S
        • Menni S
        • Docchio F
        Atopy and photosensitivity in children.
        Photodermatology. 1986; 3: 303
        • Frain-Bell W
        • Scatchard M
        The association of photosensitivity and atopy in the child.
        Br J Dermatol. 1971; 85: 105-110
        • Kawamoto T
        • Yoshiike T
        • Aikawa Y
        • Ogawa H
        Cutaneous photosensitivity in patients with atopic dermatitis.
        Jpn J Dermatol. 1992; 102: 1559-1561
      1. Kochevar E, Pathak MA, Parrish JA. Photophysics, photochemistry and photobiology. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, editors. Dermatology in General Medicine. New York, 1987;1441–1451.

        • Tanaka K
        • Watanabe M
        • Ohgami T
        • Nonaka S
        • Yoshida H
        A case of photocontact dermatitis due to suprofen.
        Nishinihon J Dermatol. 1991; 53: 695-698
        • Higashi K
        • Katayama I
        • Mukai H
        • Nishioka K
        Poikiloderma-like skin lesion induced by Prednisolone valerate acetate ointment and ultraviolet ray irradiation.
        Nishinihon J Dermatol. 1988; 50: 871-874
        • Kato Naoka
        A case of photosensitive drug eruption induced by mequitazine.
        Nishinihon J Dermatol. 1992; 54: 37-41
        • Kurumaji Y
        • Kondo S
        • Fukuro S
        • Keong CH
        • Nishioka K
        Chronic actinic dermatitis in a young patient with atopic dermatitis.
        J Am Acad Dermatol. 1994; 31: 667-669
        • Ichikawa H
        • Soma T
        • Hirao T
        • Sato Y
        • Fukushima S
        Adjuvant-induced persistent photosensitivity models in guinea pig I. Induction of persistent photosensitivity.
        J Dermatol Sci. 1995; 9: 1-6
        • Ichikawa H
        • Soma T
        • Hirao T
        • Sato Y
        • Fukushima S
        Adjuvant-induced persistent photosensitivity models in guinea pig. II. Characterization of immunological mechanisms.
        J Dermatol Sci. 1995; 9: 7-11