Abstract
Quinolone antibacterial agents are well known to elicit photosensitivity as a side
effect. The photoallergenicity of fluoroquinolones, the representative quinolone derivatives,
is mainly derived from their photohaptenic moiety. When epidermal cells are irradiated
with ultraviolet A light in the presence of fluoroquinolones, quinolone photoadducts
are formed in the treated cells. This photomodification is thought to be an initial
step for sensitization and elicitation of this photoallergy, and quinolone-photoderivatized
Langerhans cells are capable of stimulating immune T cells in mice. In the murine
model, fluoroquinolone photoallergy is mediated by Th1 cells bearing T cell receptor
Vβ13. There is a broad photoantigenic cross-reactivity among fluoroquinolones in recognition
by T cells and immunoglobulins. Therefore, it is most likely that fluoroquinolones
carry the same photoantigenic epitope, which is recognized by Vβ13+ T cells, leading to fluoroquinolone photosensitivity and cross-reactivity.
Keywords
Abbreviations:
CPFX, ciprofloxacin (), ELISA, enzyme-linked immunosorbent assay (), ENX, enoxacin (), FLRX, fleroxacin (), Ig, immunoglobulin (), IL, interleukin (), LC, Langerhans cells (), LFLX, lomefloxacin (), LVLX, levofloxacin (), mAb, monoclonal antibody (), MHC, major histocompatibility complex (), NFLX, norfloxacin (), OFLX, ofloxacin (), PBMC, peripheral blood mononuclear cells (), SPFX, sparfloxacin (), TCSA, 3,3′,4′,5-tetrachlorosalicylanilide (), TFLX, tosufloxacin (), UVA, ultraviolet A light (), UVB, ultraviolet B light ()To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
April 6,
1998
Received:
March 25,
1998
Identification
Copyright
© 1998 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
